https://en.wikipedia.org/wiki/Urtica_dioica The plant has a long history of use as a source for traditional medicine, food, tea, and textile raw material in ancient and modern societies. Urtica dioica produces its inflammatory effect on skin (stinging, burning sensation often called "contact urticaria") both by impaling the skin via spicules – causing mechanical irritation – and by biochemical irritants, such as histamine, serotonin, and acetylcholine, among other chemicals. 5992
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